frequently asked questions about INVOKANA®

here are some brief answers to some commonly asked questions—but it’s important to talk to your doctor to answer any questions you may have about INVOKANA®

Yes. INVOKANA® was the first SGLT2 inhibitor in the US—the latest class of medicines that work with the kidneys to lower A1C—with more prescriptions written than any other medication in the class since launch. In addition to significantly lowering A1C, it’s the only type 2 diabetes pill approved to lower the risk of major cardiovascular events including heart attack, stroke, and cardiovascular death.

Because of the way SGLT2 inhibitors like INVOKANA® work, they can help lower your blood sugar by removing it from your body through urination. Only INVOKANA® has been proven to work with your kidneys to help you lose about 100 grams of sugar a day through the process of urination.

It’s important to keep track of your blood sugar levels as directed by your doctor. Consider keeping a journal, or if your doctor recommends daily testing, try using a OneTouch® Meter—and share your progress at your next appointment. Your doctor will check your diabetes with regular blood tests, including tests of your blood sugar levels and your A1C.

Take INVOKANA® by mouth 1 time each day exactly as your doctor tells you to take it. It is best to take INVOKANA® before the first meal of the day. Your doctor will tell you when and how much INVOKANA® to take. Your doctor may change your dose if needed.

If you miss a dose, take it as soon as you remember. If you do not remember until it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take 2 doses of INVOKANA® at the same time.

Although INVOKANA® is not a weight-loss medicine, and each person is different, people can experience reduction in weight—on average 2–3%. Results may vary by dose and when used alone or with certain other diabetes medications.

INVOKANA® may increase your risk of lower-limb amputations. In a recent study called the CANVAS trial, INVOKANA® was studied in a group of over 10,000 adults who had type 2 diabetes for an average of 13.5 years. In this program, an increased risk of amputations, mostly, but not limited to, toes and feet was observed (2.4% in the INVOKANA® group vs 1.1 % in the placebo group).

  • During the program, a total of 187 patients out of more than 10,000 patients had a lower-limb amputation—representing an increase in the INVOKANA® group over the placebo (sugar pill) group that was equal to about one more amputation for every 100 patients over the course of 3 years.
  • Nearly all (nine out of ten) patients taking INVOKANA® who had an amputation in the study had one or more of the following conditions: lower-limb infection, gangrene, foot ulcer, poor circulation, and/or a history of prior amputation. Please see Medication Guide, including Boxed Warning, and Important Safety Information for more information.
  • This increased risk of amputation was not seen during 12 other completed INVOKANA® clinical trials that included more than 8,000 patients with type 2 diabetes.

People with type 2 diabetes are more likely to have foot problems, including amputations. Be sure to wash and inspect your feet every day, and seek care early if you notice any changes in your feet. You may be at a higher risk of lower-limb amputation if you: have a history of amputation, have heart disease or are at risk for heart disease, have had blocked or narrowed blood vessels usually in your leg, have damage to the nerves (neuropathy) in your leg, have had diabetic foot ulcers or sores.

Call your doctor right away if you have new pain or tenderness, any sores, ulcers, or infections in your leg or foot.

Prescription medication is more likely to be safe and effective if you take the medication exactly as directed. Your doctor will tell you how much INVOKANA® to take, and when to take it. Always talk to your doctor before changing how you take your medication. Need a little help remembering to take your medication? Our Care4Today® mobile app puts pill and refill reminders in the palm of your hand. Get the app

Yes. INVOKANA® will cause your urine to test positive for glucose.

Yeast infections of the vagina may be minimized by avoiding douches, tight undergarments, and scented hygiene products. Yeast infections of the penis may be minimized by regular washing with soap and water, including under the foreskin if you are uncircumcised. Talk to your doctor about what to do if you get symptoms of a yeast infection of the vagina or penis. If your doctor suggests an over-the-counter antifungal medicine and your symptoms do not go away, talk with your doctor right away.

The Janssen CarePath Savings Program for INVOKANA® allows eligible patients using commercial or private insurance to save on out-of-pocket costs for INVOKANA®. Depending on the health insurance plan, savings may apply toward co-pay, co-insurance or deductible.

Most patients with commercial or private insurance who are eligible pay $0 per month, with a $3000 maximum program benefit per calendar year, subject to monthly program benefit limits. There is no limit for the first month; $200 limit for each month thereafter. Not valid for patients using Medicare, Medicaid, or other government-funded programs to pay for their medications. Terms expire at the end of each calendar year and may change. See full eligibility requirements.

Once you have activated your savings card, you’re eligible to receive instant savings on the out-of-pocket prescription costs you’ve paid after activation. If you’ve already paid your co-pay, you can receive a rebate by completing a rebate form, including the pharmacy receipt, and following the instructions on the form. Click

to get started.